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ea0029p507 | Diabetes | ICEECE2012

QRFP43 and its fragment 26RFa both promote β-cell survival but differently regulate insulin secretion and glucose uptake in pancreatic β-cells and human pancreatic islets

Trovato L. , Settanni F. , Gallo D. , Gargantini E. , Bergandi L. , Ong H. , Ghigo E. , Granata R.

RFamides are a family of peptides containing arginine-phenylalanine-amide at their C terminus. A novel 43-amino acid RFamide, named QRFP43, and a shorter endogenous peptide 26RFa, were discovered and identified as ligands of the G protein-coupled receptor GPR103. Different studies have shown that RFamides, such as neuropeptide FF and QRFP43 and 26RFa, play a role in food intake, thermogenesis and energy homeostasis. Here, we investigated the effects of QRFP peptides on surviva...

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ea0029oc4.1 | Pituitary Basic | ICEECE2012

Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in primates and mice

Luque R. , Cordoba-Chacon J. , Grande C. , Gesmundo I. , Gahete M. , Gallo D. , Pozo-Salas A. , Ghigo E. , Granata R. , Kineman R. , Castano J.

Obestatin is a 23-amino acid amidated peptide that is encoded by the ghrelin gene and was therefore presumed to have regulatory effects on pituitary. However, the limited set of studies performed hitherto suggests that obestatin has no major effect on hormone secretion, in vivo or in vitro, from rodent pituitary, whereas no comparable data is still available on primates. Here, primary pituitary cell cultures from a non-human primate (baboon; Papio anubis) served ...

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Endocrine Abstracts

QRFP43 and its fragment 26RFa both promote β-cell survival but differently regulate insulin secretion and glucose uptake in pancreatic β-cells and human pancreatic islets

Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in primates and mice

BiosciAbstracts